abstract：:Gilbert syndrome (GS) is a hereditary unconjugated hyperbilirubinemia that results from mutations in the bilirubin uridine diphosphate-glucuronosyltransferase (UGT1A1) gene. To the best of our knowledge, there are currently no reports that focus on patients with systemic lupus erythematosus (SLE) coexisting with GS. T...

journal_title：Experimental and therapeutic medicine

authors： Ye N,Zhou Z,Gong H,Teng J,Han Y,Yang C,Ye J

更新日期：2020-11-01 00:00:00

abstract：:Hyponatremia is a risk factor associated with poor prognosis in patients with heart failure (HF) with reduced ejection fraction. However, whether hyponatremia has a similar role in patients with HF with preserved ejection fraction (HFpEF) has remained controversial. Therefore, the present study aimed to investigate th...

journal_title：Experimental and therapeutic medicine

authors： Su Y,Ma M,Zhang H,Pan X,Zhang X,Zhang F,Lv Y,Yan C

更新日期：2020-11-01 00:00:00

abstract：:Aldehyde dehydrogenase 2 (aldh2) serves an important role in the development of organ injury. Therefore, the present study investigated the effects of aldh2 on the oxidative stress response in a mouse model of ketamine-induced cystitis (KIC). A total of 60 8-week-old male Institute of Cancer Research wild-type (WT) mi...

journal_title：Experimental and therapeutic medicine

authors： Xi XJ,Chen SH,Mi H

更新日期：2020-11-01 00:00:00

abstract：:The present study aimed to investigate the effects of mechanical stretch and lipopolysaccharides (LPS) on the expression of transforming growth factor-β1 (TGF-β1) and collagen and viscoelasticity in human embryonic MRC-5 lung fibroblasts cultured in vitro and to assess the mechanisms of ARDS-associated ventilator-indu...

journal_title：Experimental and therapeutic medicine

authors： Xie Y,Qian Y,Wang Y,Liu K,Li X

更新日期：2020-11-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is a common malignant tumor with poor prognosis and an increasing number of cases. MicroRNA (miR)-4728 is related with the progression of various types of cancer, and is dysregulated in NSCLC, which indicates that miR-4728 may serve as a biomarker for NSCLC. The present study aimed t...

journal_title：Experimental and therapeutic medicine

authors： Hu Y,Zhang X,Gong C,Li J

更新日期：2020-11-01 00:00:00

abstract：:Corneal astigmatism significantly compromises uncorrected visual acuity (UCVA) after phacoemulsification with implantation of traditional spherical or non-spherical monofocal intraocular lens (IOL). Toric IOL provides an effective way to gain favorable postoperative UCVA for the patients with cataracts with corneal as...

journal_title：Experimental and therapeutic medicine

authors： Yang JJ,Qin YZ,Qin L,Li JM

更新日期：2020-11-01 00:00:00

abstract：:Multi infarct dementia (MID) is a form of dementia that is preventable and treatable. However, at present, the drugs used in MID treatment were developed for Alzheimer's disease. While only a limited range of drugs is available, the incidence of MID is increasing year on year. The present study aimed to investigate th...

journal_title：Experimental and therapeutic medicine

authors： Fu Y,Wei J,Li B,Gao L,Xia P,Wen Y,Xu S

更新日期：2020-11-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial proliferation and inflammation. Intra-articular corticosteroid injections are commonly used for the treatment of arthritis affecting one or two joints. Although corticosteroid injections are fast-acting, repeated usage can result in se...

journal_title：Experimental and therapeutic medicine

authors： Cho HK,Park GY,Sung WJ,Kawk SG,Jung WB

更新日期：2020-11-01 00:00:00

abstract：:Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase (HMGCS2) deficiency is a metabolic disorder caused by mutations in the HMGCS2 gene. The present study describes the identification of four cases of HMGCS2 deficiency in Japan. Hepatomegaly and severe metabolic acidosis were observed in all cases. Fatty liver was id...

journal_title：Experimental and therapeutic medicine

authors： Ago Y,Otsuka H,Sasai H,Abdelkreem E,Nakama M,Aoyama Y,Matsumoto H,Fujiki R,Ohara O,Akiyama K,Fukui K,Watanabe Y,Nakajima Y,Ohnishi H,Ito T,Fukao T

更新日期：2020-11-01 00:00:00

abstract：:Intrahepatic cholangiocarcinoma (ICC) is a cancer type with high malignancy and a current lack of biomarkers to predict recurrence. In the present study, to identify potential biomarkers, five ICC datasets from the Gene Expression Omnibus database were analyzed to construct initial datasets by using a robust rank aggr...

journal_title：Experimental and therapeutic medicine

authors： Chen FY,Zhou C,Zhang XY,Zhou KQ,Peng YF,Yu L,Fan J,Zhou J,Hu J,Wang Z

更新日期：2020-11-01 00:00:00

abstract：:Diabetes mellitus is becoming a major health burden worldwide. Pancreatic β-cell death is a characteristic of type 2 diabetes (T2D), but the underlying mechanisms of pancreatic β-cell death remain unknown. Therefore, the aim of the present study was to identify potential targets in the pancreatic islet of T2D. The GSE...

journal_title：Experimental and therapeutic medicine

authors： Zhou DY,Mou X,Liu K,Liu WH,Xu YQ,Zhou D

更新日期：2020-11-01 00:00:00

abstract：:COVID-19 pandemic is a reality. This study extracted information from a case in Italy and a case in South Korea during COVID-19 pandemic. Epidemic threat evolved differently in Italy compared to that in South Korea. Case fatality ratios from Italy and South Korea were consistently diverging over time. It appears that ...

journal_title：Experimental and therapeutic medicine

authors： Symvoulakis EK,Sourvinos G,Spandidos DA,Lionis C

更新日期：2020-11-01 00:00:00

abstract：:Stress-related mucosal disease (SRMD) is a common complication in patients in the intensive care unit (ICU). The aim of the present study was to investigate the possible mechanisms for the pathogenesis of SRMD. In total, 38 patients with SRMD were enrolled from an ICU, as well as 15 healthy volunteers. The disease sev...

journal_title：Experimental and therapeutic medicine

authors： Wang X,Zhao Q,Shi H,Qi F,Shi N,Bai D,Li X,Yuan H,Zuo X

更新日期：2020-11-01 00:00:00

abstract：:Previous studies have demonstrated that various microRNAs (miRNAs or miRs) are abnormally expressed in osteosarcoma (OS) and serve roles in its malignant development. An in-depth understanding of the specific roles of dysregulated miRNAs in OS may be important for cancer research and the identification of novel therap...

journal_title：Experimental and therapeutic medicine

authors： Jin Y,Yang L,Li X

更新日期：2020-10-01 00:00:00

abstract：:The aim of the present study was to retrospectively analyse the multi-slice spiral CT (MSCT) findings of radiation colitis and rectitis (RC&R). A total of 23 cases of RC&R detected by helical CT were included. The CT findings and clinical and endoscopy data of the patients were reviewed. The primary tumours included c...

journal_title：Experimental and therapeutic medicine

authors： Xiao J,Li QD

更新日期：2020-10-01 00:00:00

abstract：:Cisplatin (DDP) is a commonly used chemotherapy drug; however, the side effects associated with its use, particularly acute kidney injury (AKI), limit its clinical application. Puerarin is a natural flavonoid extracted from the Chinese medical herb Radix puerariae, which has been reported to alleviate DDP-induced neph...

journal_title：Experimental and therapeutic medicine

authors： Wu Z,Li C,Li Q,Li J,Lu X

更新日期：2020-10-01 00:00:00

abstract：:Visual inspection via laparoscopy is considered the gold standard for the diagnosis of deep infiltrating endometriosis. Laparoscopy is an invasive procedure; therefore, it would be beneficial to patients if accurate non-invasive modalities were available for the diagnosis of deep infiltrating endometriosis. The purpos...

journal_title：Experimental and therapeutic medicine

authors： Zhang X,He T,Shen W

更新日期：2020-10-01 00:00:00

abstract：:Sepsis is a complication of infection caused by disease or trauma. Increasing evidence have shown that long noncoding RNAs (lncRNAs) are involved in the regulation of sepsis. However, the mechanism of lncRNA nuclear enriched abundant transcript 1 (NEAT1) in the regulation of sepsis progression remains to be elucidated...

journal_title：Experimental and therapeutic medicine

authors： Liu L,Liu F,Sun Z,Peng Z,You T,Yu Z

更新日期：2020-10-01 00:00:00

abstract：:The present study aimed to evaluate the value of serum amyloid A (SAA) in coronavirus disease 2019 (COVID-19) and compared the efficacy of SAA and C-reactive protein (CRP) in predicting the severity and recovery of COVID-19. A retrospective study was conducted on COVID-19 patients hospitalized in Wuhan No. 1 Hospital ...

journal_title：Experimental and therapeutic medicine

authors： Fu J,Huang PP,Zhang S,Yao QD,Han R,Liu HF,Yang Y,Zhang DY

更新日期：2020-10-01 00:00:00

abstract：:Hepatitis B virus (HBV) can establish a lifelong chronic infection in humans, leading to liver cirrhosis, liver failure and hepatocellular carcinoma. Patients with chronic hepatitis B (CHB) exhibit a weak virus-specific immune response. Regulatory T cells (Tregs) play a key role in regulating the immune response in pa...

journal_title：Experimental and therapeutic medicine

authors： Tang R,Lei Z,Wang X,Qi Q,He J,Liu D,Wang X,Chen X,Zhu J,Li Y,Zhou S,Su C

更新日期：2020-10-01 00:00:00

abstract：:Effects of antithrombotic agents on the bleeding risk after transurethral resection of the prostate (TURP) were assessed in patients with benign prostatic hyperplasia (BPH). Controlled clinical trials on the effects of perioperative anticoagulant therapy on postoperative bleeding in BPH patients published during Janua...

journal_title：Experimental and therapeutic medicine

authors： He Q,Yu Y,Gao F

更新日期：2020-10-01 00:00:00

abstract：:Aggressive behavior is one of the main characteristics of different psychiatric disorders such as: personality disorders (antisocial personality disorder, borderline personality disorder), schizophrenia, intermittent explosive disorder, post-traumatic stress disorder, bipolar disorder, depression, alcohol/substance in...

journal_title：Experimental and therapeutic medicine

authors： Trifu SC,Tudor A,Radulescu I

更新日期：2020-10-01 00:00:00

abstract：:Due to the wide introduction of screening tests, patients with neoplastic diseases of the uterine cervix trend to be diagnosed in early stages of the disease, and less invasive surgical procedures are needed in certain cases. In this respect, the technique of sentinel lymph node dissection has been widely implemented ...

journal_title：Experimental and therapeutic medicine

authors： Bacalbasa N,Balescu I,Diaconu C,Savu C,Savu C,Neacsu A,Belu E,Bratu O,Cretoiu D,Halmaciu I,Iliescu L,Balalau C,Filipescu A,Vilcu M,Brezean I

更新日期：2020-10-01 00:00:00

abstract：:This review presents a systematic analysis of the literature regarding the pachychoroid disease spectrum nomenclature, diagnosis criteria and therapeutic options. Pachychoroid related diseases are a new concept, introduced into the ophthalmological nomenclature in 2013 and evolving both as concept and as classificatio...

journal_title：Experimental and therapeutic medicine

authors： Moraru AD,Costin D,Moraru RL,Costuleanu M,Brănișteanu DC

更新日期：2020-10-01 00:00:00

abstract：:Coronary artery disease (CAD) is the first cause of morbidity and mortality worldwide. An important goal is to diagnose patients in early stages, in order to reduce acute cardiovascular events. The angiotensin-converting enzyme (ACE) is an important element for the cardiovascular system, through its actions on hydro-s...

journal_title：Experimental and therapeutic medicine

authors： Vladeanu MC,Bojan IB,Bojan A,Iliescu D,Badescu MC,Badulescu OV,Badescu M,Georgescu CA,Ciocoiu M

更新日期：2020-10-01 00:00:00

abstract：:Stem cells represent an old niche with various new potential therapeutics. Besides drug treatment, reperfusion procedures and surgical revascularization, stem cell therapy could be a good option in ischemic cardiac diseases. A study was performed on a small group of cases who died of cardiac arrhythmia secondary to sc...

journal_title：Experimental and therapeutic medicine

authors： Ceausu Z,Socea B,Dimitriu MCT,Predescu D,Constantin VD,Bacalbaşa N,Cîrstoveanu C,Costache M,Ceausu M

更新日期：2020-10-01 00:00:00

abstract：:Capillary density on nailfold capillaroscopy (NFC) is considered a promising instrument for assessing disease characteristics in patients with systemic sclerosis (SSc), however, there is no agreement yet over how to analyze and interpret the results. The objective of this study was to investigate the possible associat...

journal_title：Experimental and therapeutic medicine

authors： Gheorghiu AM,Oneata R,Ancuta I,Enuica A,Linte O,Macovei L,Bojinca M,Stoica V,Mihai C

更新日期：2020-10-01 00:00:00

abstract：:Toxoplasmosis is a zoonotic infection caused by the obligate intracellular apicomplexan parasite Toxoplasma gondii (T. gondii). T. gondii infection is a cause of congenital infection worldwide. Primary infection or the reactivation of latent infection during pregnancy may lead to fetal infection and to congenital toxo...

journal_title：Experimental and therapeutic medicine

authors： Motoi S,Navolan DB,Malita D,Ciohat I,Nemescu D,Manciuc C,Gorun F,Vilibic-Cavlek T,Boda D,Craina M,Dobrescu A

更新日期：2020-10-01 00:00:00

abstract：:Asthma in children poses a threat to their health, but the mechanism remains to be elucidated. The present study investigated the mechanism by which the interleukin (IL)-22/IL-22 receptor 1 (IL-22R1) signaling pathway regulates subepithelial fibrosis in children with asthma. A total of 41 children with asthma and 12 h...

journal_title：Experimental and therapeutic medicine

authors： Liu J,Shang B,Bai J

更新日期：2020-09-01 00:00:00

abstract：:Tuberculosis is highly infectious and has a high incidence worldwide. Therefore, effective treatment is essential for the disease. The immune function and inflammatory factors can reflect the therapeutic effect of pulmonary tuberculosis to some extent. Thus, the aim of the present study was to investigate the clinical...

journal_title：Experimental and therapeutic medicine

authors： Cheng C,Pan W,Li X,Qu H

更新日期：2020-09-01 00:00:00

abstract：:One of the critical factors for predicting the success of percutaneous catheter drainage (PCD) is the mean CT density of collection. A higher CT density suggests more necrotic solid tissue within the collection. In the present study, a novel technique for PCD of the necrotic pancreatic collection with a higher mean CT...

journal_title：Experimental and therapeutic medicine

authors： Gupta P,Koshi S,Samanta J,Mandavdhare H,Sharma V,K Sinha S,Dutta U,Kochhar R

更新日期：2020-09-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) has a high prevalence in type 2 diabetes mellitus (T2DM) patients, being one of the disorders with a relevant global burden. Cross-sectional studies have shown that patients with T2DM and NAFLD have a higher prevalence of liver fibrosis, compared with the general population. P...

journal_title：Experimental and therapeutic medicine

authors： Bica C,Sandu C,Suceveanu AI,Sarbu E,Stoica RA,Gherghiceanu F,Bohiltea RE,Stefan SD,Stoian AP

更新日期：2020-09-01 00:00:00

abstract：:Cytomegalovirus (CMV) infection is the most common congenital infection worldwide, and remains a significant cause of the neurological deficiency and sensory deafness in developed countries. Maternal primary infection, reactivation or reinfection during pregnancy may lead to fetal infection and congenital CMV syndrome...

journal_title：Experimental and therapeutic medicine

authors： Gorun F,Motoi S,Malita D,Navolan DB,Nemescu D,Olariu TR,Craina M,Vilibic-Cavlek T,Ciohat I,Boda D,Dobrescu A

更新日期：2020-09-01 00:00:00

abstract：:The present study aims to raise awareness about the necessity of a thorough differential diagnosis process when diagnosing paraganglioma as it is an extremely rare entity with a high malignant potential. A 64-year-old female patient was admitted to the hospital with symptoms of bowel obstruction and a palpable abdomin...

journal_title：Experimental and therapeutic medicine

authors： Iliesiu A,Ungureanu IA,Petca A,Constantin MM,Petca RC,Sandru F,Constantin T,Dumitrascu MC

更新日期：2020-09-01 00:00:00

abstract：:Medical ozone is used to treat various diseases, including numerous pathologies associated with chronic pain. Chronic pain may be treated by systemic administration of ozone, with ozonated autohemotherapy (OAH) being the commonly used method. In the clinic, intravenous infusion of ozonized saline has been used to trea...

journal_title：Experimental and therapeutic medicine

authors： Ma L,Wen S,Yuan J,Zhang D,Lu YL,Zhang Y,Li Y,Cao S

更新日期：2020-09-01 00:00:00

abstract：:The present study aimed to investigate changes in the levels of metabolites and appetite control factors caused by different dietary interventions in Sprague Dawley (SD) rats. A total of 35 male SD rats were weaned and immediately randomly assigned to five groups. The control group was given ad libitum access to a nor...

journal_title：Experimental and therapeutic medicine

authors： Lin B,Liu Y,Zhang W,Zou W

更新日期：2020-09-01 00:00:00

abstract：:Bone marrow stromal cells (MSCs) are a useful source of stem cells for the treatment of various brain injury diseases due to their abundant supply and fewer ethical problems compared with transplant treatment. However, the clinical application of MSCs is limited due to allograft rejection and immunosuppression in the ...

journal_title：Experimental and therapeutic medicine

authors： Yuan FY,Zhang MX,Shi YH,Li MH,Ou JY,Bai WF,Zhang MS

更新日期：2020-09-01 00:00:00

abstract：:Matrine is an active component of Leguminosae plants and is thought to exhibit anti-tumor effects. However, the effects of matrine on drug-resistant cancer have not been fully elucidated. The present study aimed to investigate the effects of matrine on vincristine (VCR)-resistant retinoblastoma (RB) cells and to asses...

journal_title：Experimental and therapeutic medicine

authors： Zhao B,Li B,Liu Q,Gao F,Zhang Z,Bai H,Wang Y

更新日期：2020-09-01 00:00:00

abstract：:Breast cancer remains a worldwide public-health issue. Novel drugs that increase the sensitivity and reduce the toxic side effects of chemotherapeutic agents are urgently required. The present study investigated the effect and mechanism of the short-term intermittent administration of an anticancer bioactive peptide (...

journal_title：Experimental and therapeutic medicine

authors： Li X,Gao B,Su X

更新日期：2020-09-01 00:00:00

abstract：:Compared with traditional imaging techniques, multimodal imaging obtains more accurate images that may increase disease detection rates. The present study prepared stromal cell-derived factor 1 (SDF-1)-loaded, targeted nanoparticles coated with iron (II,III) oxide and perfluorohexane (PFH) to be used as polymer-shelle...

journal_title：Experimental and therapeutic medicine

authors： Wang F,Wang Z,Pang L,Wan S,Qiu L

更新日期：2020-09-01 00:00:00